Tissue expression
Cell line expression
Protein structure
RPE65
Retinoid isomerohydrolase RPE65BCO3, LCA2, rd12, RP20
The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
Top validated antibodies |
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Invitrogen Antibodies | MA1-16578 | 6 references | Monoclonal |
WB
ICC
IHC
FC
OA
|
|
Novus Biologicals | NB100-355 | 64 references | Monoclonal |
WB
ICC
IHC
FC |
|
antibodies-online | ABIN151819 | 47 references | Monoclonal |
WB
ICC
IHC
FC |
|
GeneTex | GTX13826 | 1 references | Monoclonal |
WB
ICC
IHC
FC |
|
Proteintech Group | 17939-1-AP | 5 references | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider