MSH4

This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]

Description

MutS homolog 4

Tissue specificity

Tissue enhanced (brain, epididymis, testis)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

1 (75796882 - 75913242)

Ensembl ID

ENSG00000057468  (ver. 103.38)

Orthologs

Mouse Msh4: ENSMUSG00000005493

UniProt

O15457

neXtProt

NX_O15457

Human splice variants
Mouse splice variants

Protein structure