SMOC2

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

SPARC related modular calcium binding 2

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane, Secreted to extracellular matrix

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (168441151 - 168673445)

Ensembl ID

ENSG00000112562  (ver. 103.38)

Orthologs

Mouse Smoc2: ENSMUSG00000023886

UniProt

Q9H3U7

neXtProt

NX_Q9H3U7

Human splice variants
Mouse splice variants

Protein structure