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Protein structure
TNFSF11
TNF superfamily member 11CD254, ODF, OPGL, RANKL, TRANCE
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NB100-56512 |
29 references | Monoclonal |
WB
EL
ICC
IHC
ChIP
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| Invitrogen Antibodies | PA5-110268 |
3 references | Polyclonal |
WB
ICC
IHC
OA
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| antibodies-online | ABIN252476 |
20 references | Monoclonal |
WB
ICC
IHC
FC
ChIP
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| R&D Systems | AF462 |
14 references | Polyclonal |
WB
EL
IHC
BN
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| Proteintech Group | 23408-1-AP |
53 references | Polyclonal |
WB
EL
IHC
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