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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [7]
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- Product number
- ABIN401345 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Epithelial Cell Transforming Sequence 2 Oncogene (ECT2) (AA 785-795), (pThr790) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide corresponding to amino acids 785-795 of human ECT2 protein
- Description
- Affinity chromatography
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Zebrafish
- Host
- Rabbit
- Epitope
- AA 785-795,pThr790
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.31 mg/mL (by UV absorbance at 280 nm)
- Storage
- -20°C
- Handling
- Avoid repeated freezing and thawing.
Submitted references MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.
Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
Zhao WM, Fang G
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13158-63
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13158-63
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
Niiya F, Xie X, Lee KS, Inoue H, Miki T
The Journal of biological chemistry 2005 Oct 28;280(43):36502-9
The Journal of biological chemistry 2005 Oct 28;280(43):36502-9
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S
The Journal of cell biology 2005 Jan 17;168(2):221-32
The Journal of cell biology 2005 Jan 17;168(2):221-32
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.
Kim JE, Billadeau DD, Chen J
The Journal of biological chemistry 2005 Feb 18;280(7):5733-9
The Journal of biological chemistry 2005 Feb 18;280(7):5733-9
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.
Liu XF, Ishida H, Raziuddin R, Miki T
Molecular and cellular biology 2004 Aug;24(15):6665-75
Molecular and cellular biology 2004 Aug;24(15):6665-75
Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.
Saito S, Tatsumoto T, Lorenzi MV, Chedid M, Kapoor V, Sakata H, Rubin J, Miki T
Journal of cellular biochemistry 2003 Nov 1;90(4):819-36
Journal of cellular biochemistry 2003 Nov 1;90(4):819-36
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.
Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T
The Journal of cell biology 1999 Nov 29;147(5):921-8
The Journal of cell biology 1999 Nov 29;147(5):921-8
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