653903

antibody from BioLegend
Targeting: PYCARD ASC, CARD5, TMS-1
Provider product page for 653903

Antibody data

Product number
653903 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#653903, RRID:AB_2564507
Product name
PE anti-ASC (TMS-1)
Antibody type
Monoclonal
Antigen
Recombinant human ASC (aa 113-195).
Description
Apoptosis-associated speck-like protein containing a CARD (ASC), also known as target of methylation-mediated silencing (TMS1) and PYD and CARD domain containing protein (PYCARD), is a 22 kD pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD). The TMS1 gene was originally found to be aberrantly methylated and silenced in various cancer cells. Expression of ASC can be induced by pro-apoptotic/inflammatory stimuli. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. During apoptosis, ASC translocated from the cytosol to the mitochondria and associates with mitochondrial Bax to trigger cytochrome c release and subsequent apoptosis. The adaptor molecule ASC mediates AIM2-dependent caspase-1 activation. Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform. Moreover, emerging reports show novel roles for ASC in disease conditions such as arthritis.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Antibody clone number
HASC-71
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
PYCARD protein structure - 653903 shown in red.