CABT-BL1699

antibody from Creative Diagnostics

Targeting: GSTM4

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-BL1699

Provider

Creative Diagnostics

Product name

Anti-GSTM4 monoclonal antibody, clone AB77466

Antibody type

Monoclonal

Description

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG