BS7357

antibody from Bioworld Technology, Inc
Targeting: AP2M1 AP50, CLAPM1, mu2
Provider product page for BS7357
Western blot
Immunohistochemistry

Antibody data

Product number
BS7357 - Provider product page
Provider
Bioworld Technology, Inc
Product name
AP2M1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human AP2M1.
Description
The AP-2 coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane (1-3). Each AP-2 heterotetramer is composed of Ï«, ÉÇ, Ã×, and ¿¼ protein subunits. The 50 kDa Ã× subunit (AP-2Ã×, AP2M1) is located at the core of the AP-2 complex and mediates interaction between the cargo protein and the clathrin-coated pit (1-4). The carboxy-terminal AP2M1 region recognizes the tyrosine-based, endocytotic sorting motif YXX¶ú found in cargo proteins and helps to bring the cargo protein to the clathrin-coated pit. Non-canonical, tyrosine-based endocytotic sorting signals can also promote interaction between cargo proteins and AP2M1 (5,6). AP2M1 plays an essential role in molecular signaling as it couples receptor-mediated endocytosis and pathways involving membrane receptors (7-9), matrix metalloproteinases (10), and ion channel proteins (11). Phosphorylation of specific AP2M1 residues and binding of lipids to this adaptor protein can regulate AP2M1 activity (12,13). Phosphorylation of AP2M1 at Thr156 by adaptor-associated kinase 1 (AAK1) stimulates affinity binding of AP2M1 to cargo protein signals (14).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
AP2M1 protein structure - BS7357 shown in red.