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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- ELISA [1]
- Immunohistochemistry [1]
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- Product number
- H00253782-M01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00253782-M01, RRID:AB_2133107
- Product name
- Mouse Monoclonal LASS6 Antibody
- Antibody type
- Monoclonal
- Description
- IgG purified. LASS6 - LAG1 longevity assurance homolog 6 (S. cerevisiae)
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions.
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Modulation of ceramide synthase activity via dimerization.
D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
Mutations of optineurin in amyotrophic lateral sclerosis.
Uen YH, Fang CL, Lin CC, Hseu YC, Hung ST, Sun DP, Lin KY
Molecular carcinogenesis 2018 Dec;57(12):1675-1689
Molecular carcinogenesis 2018 Dec;57(12):1675-1689
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Li S, Wu Y, Ding Y, Yu M, Ai Z
Journal of cellular physiology 2018 Dec;233(12):9416-9425
Journal of cellular physiology 2018 Dec;233(12):9416-9425
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions.
Gerl MJ, Bittl V, Kirchner S, Sachsenheimer T, Brunner HL, Lüchtenborg C, Özbalci C, Wiedemann H, Wegehingel S, Nickel W, Haberkant P, Schultz C, Krüger M, Brügger B
PloS one 2016;11(4):e0153009
PloS one 2016;11(4):e0153009
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Suzuki M, Cao K, Kato S, Komizu Y, Mizutani N, Tanaka K, Arima C, Tai MC, Yanagisawa K, Togawa N, Shiraishi T, Usami N, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Igarashi Y, Inokuchi J, Iwaki S, Fujii S, Satou A, Matsumoto Y, Ueoka R, Tamiya-Koizumi K, Murate T, Nakamura M, Kyogashima M, Takahashi T
The Journal of clinical investigation 2016 Jan;126(1):254-65
The Journal of clinical investigation 2016 Jan;126(1):254-65
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI
The Journal of biological chemistry 2016 Jan 22;291(4):1957-73
The Journal of biological chemistry 2016 Jan 22;291(4):1957-73
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AH
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):5682-7
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):5682-7
Modulation of ceramide synthase activity via dimerization.
Laviad EL, Kelly S, Merrill AH Jr, Futerman AH
The Journal of biological chemistry 2012 Jun 15;287(25):21025-33
The Journal of biological chemistry 2012 Jun 15;287(25):21025-33
D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.
Yamane M, Miyazawa K, Moriya S, Abe A, Yamane S
Biochimie 2011 Sep;93(9):1446-59
Biochimie 2011 Sep;93(9):1446-59
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
Mullen TD, Spassieva S, Jenkins RW, Kitatani K, Bielawski J, Hannun YA, Obeid LM
Journal of lipid research 2011 Jan;52(1):68-77
Journal of lipid research 2011 Jan;52(1):68-77
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R
Cellular signalling 2010 Sep;22(9):1300-7
Cellular signalling 2010 Sep;22(9):1300-7
Mutations of optineurin in amyotrophic lateral sclerosis.
Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H
Nature 2010 May 13;465(7295):223-6
Nature 2010 May 13;465(7295):223-6
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LASS6 Antibody (5H7) [H00253782-M01] - LASS6 monoclonal antibody (M01), clone 5H7 Analysis of LASS6 expression in HeLa.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ELISA: LASS6 Antibody (5H7) [H00253782-M01] - Detection limit for recombinant GST tagged LASS6 is approximately 0.03ng/ml as a capture antibody.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: LASS6 Antibody (5H7) [H00253782-M01] - Analysis of monoclonal antibody to LASS6 on formalin-fixed paraffin-embedded human colon. Antibody concentration 3 ug/ml.
