AP0341

antibody from Bioworld Technology, Inc
Targeting: PPP1R2 IPP2, PPP1R2A
Provider product page for AP0341

Antibody data

Product number
AP0341 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IPP2 (phospho S120/S121) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human IPP2 around the phosphorylation site of Serine 120 and 121.
Description
Two inhibitors of protein phosphatase 1 (PP1) include the phosphatase inhibitor 1 (IPP-1) and phosphatase inhibitor 2 (IPP-2) . IPP-2, also known as I-2, interacts with the catalytic subunit of PP1 to form the heterodimer PP1I. The PP1I complex is present in the cytosol of cells in a broad range of vertebrate and invertebrate species. Although the heterodimer itself is inactive, a reversible phosphorylation of IPP-2 at Thr 72 by glycogen-synthase-kinase (GSK3) initiates activation of the heterodimer complex in vitro. Phosphorylation of IPP-2 by casein kinase-II at Ser 86, Ser 120, and Ser 121 enhances the rate of phosphorylation by GSK3 at Thr 72 and effectively activates the heterodimer complex. Besides moderating PP1 activity, IPP-2 may play a role as a chaperone for the correct folding of PP1.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPP1R2 protein structure - AP0341 shown in red.