SENP5

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]). [supplied by OMIM, Jun 2009]

Description

SUMO specific peptidase 5

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (196867856 - 196934714)

Ensembl ID

ENSG00000119231  (ver. 103.38)

Orthologs

Mouse Senp5: ENSMUSG00000022772

UniProt

Q96HI0

neXtProt

NX_Q96HI0

Human splice variants
Mouse splice variants

Protein structure