FLG2

The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020]

Description

Filaggrin family member 2

Tissue specificity

Tissue enriched (skin)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (152348735 - 152360006)

Ensembl ID

ENSG00000143520  (ver. 103.38)

Orthologs

Mouse Flg2: ENSMUSG00000049133

UniProt

Q5D862

neXtProt

NX_Q5D862

Human splice variants
Mouse splice variants

Protein structure