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- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 12497-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12497-1-AP, RRID:AB_2260910
- Product name
- CRTC2,TORC2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CRTC2,TORC2 antibody (Cat. #12497-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside.
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats.
CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function.
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.
CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.
Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells.
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells.
Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O
Nature metabolism 2021 May;3(5):682-700
Nature metabolism 2021 May;3(5):682-700
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Wang C, Song D, Fu J, Wen X
Frontiers in endocrinology 2020;11:580
Frontiers in endocrinology 2020;11:580
The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside.
Ling Q, Huang H, Han Y, Zhang C, Zhang X, Chen K, Wu L, Tang R, Zheng Z, Zheng S, Li L, Wang B
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Mar;20(3):701-713
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Mar;20(3):701-713
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Xu XH, Hu Q, Zhou LS, Xu LJ, Zou X, Lu FE, Yi P
Current medical science 2020 Jun;40(3):530-538
Current medical science 2020 Jun;40(3):530-538
Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats.
Song D, Yin L, Wang C, Wen X
BMC complementary medicine and therapies 2020 Jan 31;20(1):27
BMC complementary medicine and therapies 2020 Jan 31;20(1):27
CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function.
Kanki H, Sasaki T, Matsumura S, Kawano T, Todo K, Okazaki S, Nishiyama K, Takemori H, Mochizuki H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Dec 2;40(49):9533-9546
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Dec 2;40(49):9533-9546
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Song D, Yin L, Wang C, Wen X
PloS one 2019;14(6):e0210930
PloS one 2019;14(6):e0210930
Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.
Brown-Borg HM
Annals of the New York Academy of Sciences 2016 Jan;1363:40-9
Annals of the New York Academy of Sciences 2016 Jan;1363:40-9
CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
Highland JA, Weiser MJ, Hinds LR, Spencer RL
American journal of physiology. Cell physiology 2014 Oct 1;307(7):C611-21
American journal of physiology. Cell physiology 2014 Oct 1;307(7):C611-21
Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock.
Sakamoto K, Norona FE, Alzate-Correa D, Scarberry D, Hoyt KR, Obrietan K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 22;33(21):9021-7
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 May 22;33(21):9021-7
Phorbol ester-induced human cytomegalovirus major immediate-early (MIE) enhancer activation through PKC-delta, CREB, and NF-kappaB desilences MIE gene expression in quiescently infected human pluripotent NTera2 cells.
Liu X, Yuan J, Wu AW, McGonagill PW, Galle CS, Meier JL
Journal of virology 2010 Sep;84(17):8495-508
Journal of virology 2010 Sep;84(17):8495-508
Breaking human cytomegalovirus major immediate-early gene silence by vasoactive intestinal peptide stimulation of the protein kinase A-CREB-TORC2 signaling cascade in human pluripotent embryonal NTera2 cells.
Yuan J, Liu X, Wu AW, McGonagill PW, Keller MJ, Galle CS, Meier JL
Journal of virology 2009 Jul;83(13):6391-403
Journal of virology 2009 Jul;83(13):6391-403
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 12497-1-AP(CRTC2,TORC2 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using CRTC2 antibody 12497-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 12497-1-AP(CRTC2,TORC2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
