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Protein structure
NFKB1
Nuclear factor kappa B subunit 1KBF1, NF-kappaB, NF-kB1, NFkappaB, NFKB-p50, p105, p50
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]
Top validated antibodies |
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| antibodies-online |  ABIN1108443 |
2 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Atlas Antibodies | HPA027305 |
4 references | Polyclonal |
WB
ICC
IHC
ChIP
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| Invitrogen Antibodies | 51-3500 |
9 references | Polyclonal |
WB
EL
ICC
IHC
FC
GS
OA
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| LSBio | LS-C133345 |
Monoclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 14220-1-AP |
173 references | Polyclonal |
WB
EL
ICC
IP
|
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