FNab06912

antibody from FineTest Biotech
Targeting: PTEN BZS, MHAM, MMAC1, PTEN1, TEP1
Provider product page for FNab06912
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab06912 - Provider product page
Provider
FineTest Biotech
Product name
PTEN antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
phosphatase and tensin homolog
Epitope
IgG1
Isotype
IgG
Antibody clone number
9000000
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
PTEN protein structure - FNab06912 shown in red.