Ab098106

antibody from Aladdin Scientific Corporation

Targeting: CTNNA1 CAP102

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

Ab098106

Provider

Aladdin Scientific Corporation

Product name

CTNNA1 Antibody

Antibody type

Polyclonal

Description

Rabbit anti Human CTNNA1 Antibody, Polyclonal, could be used for WB, IHC, ICC/IF and so on. Application WB: 0.5-2 µg/mL IHC: 5-20 µg/mL ICC/IF: 5-20 μg/mL Protein Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Reactivity

Human, Porcine

Host

Human

Conjugate

Unconjugated

Antigen sequence

AA 2-228


Vial size

100μl,10μl,1ml,20μl,50μl

Concentration

Lot by Lot

Storage

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.