DCAF6

The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]

Description

DDB1 and CUL4 associated factor 6

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Nucleoplasm, Focal adhesion sites

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (167935783 - 168075843)

Ensembl ID

ENSG00000143164  (ver. 103.38)

Orthologs

Mouse Dcaf6: ENSMUSG00000026571

UniProt

Q58WW2

neXtProt

NX_Q58WW2

Human splice variants
Mouse splice variants

Protein structure