Tissue expression
Cell line expression
Protein structure
PPP1R15B
Protein phosphatase 1 regulatory subunit 15BFLJ14744
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
Top validated antibodies |
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Proteintech Group | 14634-1-AP | 21 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Invitrogen Antibodies | 14634-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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NovoPro Bioscience Inc. | 114153 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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FineTest Biotech | FNab06705 | Polyclonal |
WB
EL
ICC
IP
IHC
|
||
Biorbyt | orb630148 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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