KCNK2

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Potassium two pore domain channel subfamily K member 2

Tissue specificity

Tissue enriched (adrenal gland)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

1 (215005775 - 215237090)

Ensembl ID

ENSG00000082482  (ver. 103.38)

Orthologs

Mouse Kcnk2: ENSMUSG00000037624

UniProt

O95069

neXtProt

NX_O95069

Human splice variants
Mouse splice variants

Protein structure