MAB763-100

antibody from R&D Systems

Targeting: HCRT OX, PPOX

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

MAB763-100

Provider

R&D Systems

Product name

Human/Mouse/Rat Orexin A/Hypocretin-1 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from ascites. Detects human, mouse, and rat Orexin A/Hypocretin-1. In dot blots, no cross-reactivity with recombinant human Orexin B is observed.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

O43612


Isotype

IgG

Antibody clone number

97505

Vial size

100 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs.

Liguori G, Squillacioti C, Assisi L, Pelagalli A, Vittoria A, Costagliola A, Mirabella N
BMC veterinary research 2018 Feb 27;14(1):55

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Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors.

Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, Yamamoto N, Hagiwara D, Goto M, Banno R, Sugimura Y, Arima H
Scientific reports 2018 Feb 26;8(1):3615

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Localization of orexin B and receptor 2 for orexins in testicular cytotypes of the camelid alpaca (Vicugna pacos).

Liguori G, Squillacioti C, Assisi L, Mirabella N, Langella E, Costagliola A, Vittoria A
Reproduction in domestic animals = Zuchthygiene 2017 Jun;52(3):452-458

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Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 10;110(50):20260-5

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SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons.

Panossian L, Fenik P, Zhu Y, Zhan G, McBurney MW, Veasey S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 16;31(11):4025-36

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Endoplasmic reticulum stress in wake-active neurons progresses with aging.

Naidoo N, Zhu J, Zhu Y, Fenik P, Lian J, Galante R, Veasey S
Aging cell 2011 Aug;10(4):640-9

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REM sleep changes in rats induced by siRNA-mediated orexin knockdown.

Chen L, Thakkar MM, Winston S, Bolortuya Y, Basheer R, McCarley RW
The European journal of neuroscience 2006 Oct;24(7):2039-48

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Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.

Georgescu D, Zachariou V, Barrot M, Mieda M, Willie JT, Eisch AJ, Yanagisawa M, Nestler EJ, DiLeone RJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Apr 15;23(8):3106-11