P2RX1

The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]

Description

Purinergic receptor P2X 1

Tissue specificity

Tissue enhanced (bone marrow, pancreas, urinary bladder)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (3896592 - 3916476)

Ensembl ID

ENSG00000108405  (ver. 103.38)

Orthologs

Mouse P2rx1: ENSMUSG00000020787

UniProt

P51575

neXtProt

NX_P51575

Human splice variants
Mouse splice variants

Protein structure