LEFTY1

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]

Description

Left-right determination factor 1

Tissue specificity

Group enriched (intestine, pancreas)

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins

Chromosome

1 (225886282 - 225911382)

Ensembl ID

ENSG00000243709  (ver. 103.38)

Orthologs

-

UniProt

O75610

neXtProt

NX_O75610

Human splice variants

Protein structure