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PSEN1
Presenilin 1AD3, FAD, PS1, S182
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Top validated antibodies |
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| Novus Biologicals |  NB100-74510 |
6 references | Monoclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | MA1-752 |
8 references | Monoclonal |
WB
EL
ICC
IHC
OA
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| Proteintech Group | 16163-1-AP |
16 references | Polyclonal |
WB
EL
IP
IHC
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| Abcepta | AP6231A |
1 references | Polyclonal |
WB
ICC
IHC
FC
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| antibodies-online | ABIN261601 |
4 references | Monoclonal |
WB
EL
ICC
IP
IHC
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