FNab08687

antibody from FineTest Biotech

Targeting: TICAM2 TICAM-2, TIRP, TRAM

Western blot

ELISA

Immunohistochemistry

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Validation data

Product number: FNab08687 - Provider product page
Provider: FineTest Biotech
Product name: TICAM2 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: toll-like receptor adaptor molecule 2
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

TICAM2 protein structure - FNab08687 shown in red.