BS6161

antibody from Bioworld Technology, Inc
Targeting: SOX2
Provider product page for BS6161
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6161 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Sox2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Sox2.
Description
SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX 2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SOX2 protein structure - BS6161 shown in red.