Tissue expression
Cell line expression
Protein structure
HLA-DOB
Major histocompatibility complex, class II, DO betaHLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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LSBio | LS-C834900 | Polyclonal |
WB
EL
IHC
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antibodies-online | ABIN2606263 | Polyclonal |
WB
ICC
FC
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Affinity Biosciences | DF4119 | Polyclonal |
WB
EL
ICC
|
||
Biorbyt | orb1281928 | Polyclonal |
WB
EL
IHC
|
||
Abnova Corporation | H00003112-D01 | Polyclonal |
WB
IP |
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