TLR9

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

Description

Toll like receptor 9

Tissue specificity

Tissue enhanced (brain, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (52221080 - 52225645)

Ensembl ID

ENSG00000239732  (ver. 103.38)

Orthologs

-

UniProt

Q9NR96

neXtProt

NX_Q9NR96

Human splice variants

Protein structure