FNab00494

antibody from FineTest Biotech
Targeting: APOBEC3C APOBEC1L, ARDC2, ARDC4, ARP5, bK150C2.3, PBI
Provider product page for FNab00494
Western blot
ELISA
Immunohistochemistry

Antibody data

Product number
FNab00494 - Provider product page
Provider
FineTest Biotech
Product name
APOBEC3C antibody
Antibody type
Polyclonal
Antigen
Recombinant protein fragment
Description
DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus(SIV), hepatitis B virus(HBV), herpes simplex virus 1(HHV-1) and Epstein-Barr virus(EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
apolipoprotein B mRNA editing enzym
e, catalytic polypeptide-like 3C
Epitope
IgG
Isotype
IgG
Vial size
100¦Ìg
Concentration
Immunogen affinity purified
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
APOBEC3C protein structure - FNab00494 shown in red.