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- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
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- Product number
- SM7016A - Provider product page
- Provider
- Acris Antibodies GmbH
- Product name
- anti PARP1 (cleaved)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide containing amino acids near 214/215-cleavage site of human PARP
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 194C1439
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
Submitted references Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines.
Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species.
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Kamal A, Sreekanth K, Kumar PP, Shankaraiah N, Balakishan G, Ramaiah MJ, Pushpavalli SN, Ray P, Bhadra MP
European journal of medicinal chemistry 2010 Jun;45(6):2173-81
European journal of medicinal chemistry 2010 Jun;45(6):2173-81
Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species.
Ko CH, Shen SC, Chen YC
Free radical biology & medicine 2004 Apr 1;36(7):897-910
Free radical biology & medicine 2004 Apr 1;36(7):897-910
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.
Chen YC, Shen SC, Lin HY
Biochemical pharmacology 2003 Oct 1;66(7):1139-50
Biochemical pharmacology 2003 Oct 1;66(7):1139-50
Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, Tseng SW
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
Biochemical pharmacology 2002 Dec 15;64(12):1713-24
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Supportive validation
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- Acris Antibodies GmbH (provider)
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- Experimental details
- Western blot analysis of cleaved PARP in staurosporine-treated Jurkat cells at various time points, using SM7016P at 2 ug/ml. The band corresponding to cleaved PARP is only seen in the treated samples. Anti-Mouse Ig HRP conjugate was used in this test.
