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- Antibody Data
- Antigen structure
- References [27]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10255-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10255-1-AP, RRID:AB_2279733
- Product name
- HDAC3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC3 antibody (Cat. #10255-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility.
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.
CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle.
Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast.
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920
Cancer communications (London, England) 2021 Sep;41(9):904-920
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Chen Z, Huo D, Li L, Liu Z, Li Z, Xu S, Huang Y, Wu W, Zhou C, Liu Y, Kuang M, Wu F, Li H, Qian P, Song G, Wu X, Chen J, Hou Y
The Journal of experimental medicine 2021 May 3;218(5)
The Journal of experimental medicine 2021 May 3;218(5)
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Zhang K, Hussain T, Wang J, Li M, Wang W, Ma X, Liao Y, Yao J, Song Y, Liang Z, Zhou X, Xu L
Frontiers in microbiology 2020;11:433
Frontiers in microbiology 2020;11:433
Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.
Ma L, Qi L, Li S, Yin Q, Liu J, Wang J, She C, Li P, Liu Q, Wang X, Li W
Thoracic cancer 2020 Sep;11(9):2493-2505
Thoracic cancer 2020 Sep;11(9):2493-2505
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
Zheng D, Jiang Y, Qu C, Yuan H, Hu K, He L, Chen P, Li J, Tu M, Lin L, Chen H, Lin Z, Lin W, Fan J, Cheng G, Hong J
The American journal of pathology 2020 Nov;190(11):2267-2281
The American journal of pathology 2020 Nov;190(11):2267-2281
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility.
Cheng YM, Peng Z, Chen HY, Pan TT, Hu XN, Wang F, Luo T
Human reproduction (Oxford, England) 2020 Mar 27;35(3):494-503
Human reproduction (Oxford, England) 2020 Mar 27;35(3):494-503
Downregulation of HDAC8 expression decreases CD163 levels and promotes the apoptosis of macrophages by activating the ERK signaling pathway in recurrent spontaneous miscarriage.
Yao Y, Hao F, Tang LC, Xu XH, Jin L
Molecular human reproduction 2020 Jul 1;26(7):521-531
Molecular human reproduction 2020 Jul 1;26(7):521-531
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
Zhang Y, Cao X, Li P, Fan Y, Zhang L, Ma X, Sun R, Liu Y, Li W
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
Gao Y, Liu B, Feng L, Sun B, He S, Yang Y, Wu G, E G, Liu C, Gao Y, Zhang E, Zhu B
Frontiers in oncology 2019;9:33
Frontiers in oncology 2019;9:33
The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro.
Zhang H, Ji L, Yang Y, Wei Y, Zhang X, Gang Y, Lu J, Bai L
Frontiers in physiology 2019;10:1060
Frontiers in physiology 2019;10:1060
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Klf4 Promotes Dentinogenesis and Odontoblastic Differentiation via Modulation of TGF-β Signaling Pathway and Interaction With Histone Acetylation.
Tao H, Lin H, Sun Z, Pei F, Zhang J, Chen S, Liu H, Chen Z
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Aug;34(8):1502-1516
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Aug;34(8):1502-1516
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Chinese medical journal 2018 Sep 5;131(17):2080-2088
HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.
Duan H, Zhou K, Zhang Y, Yue P, Wang T, Li Y, Qiu D, Wu J, Hua Y, Wang C
Placenta 2017 Oct;58:105-114
Placenta 2017 Oct;58:105-114
Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.
Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C
Chinese medical journal 2017 Jun 5;130(11):1352-1360
Chinese medical journal 2017 Jun 5;130(11):1352-1360
The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.
Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y
Placenta 2017 Jan;49:37-47
Placenta 2017 Jan;49:37-47
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Histone deacetylase inhibitor apicidin increases expression of the α-secretase ADAM10 through transcription factor USF1-mediated mechanisms.
Hu XT, Zhu BL, Zhao LG, Wang JW, Liu L, Lai YJ, He L, Deng XJ, Chen GJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1482-1493
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1482-1493
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.
He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, Liu MF
Oncogene 2016 Nov 17;35(46):6015-6025
Oncogene 2016 Nov 17;35(46):6015-6025
CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.
Liu RZ, Garcia E, Glubrecht DD, Poon HY, Mackey JR, Godbout R
Molecular cancer 2015 Jul 5;14:129
Molecular cancer 2015 Jul 5;14:129
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle.
Yuan H, Niu Y, Liu X, Fu L
Acta physiologica (Oxford, England) 2014 Dec;212(4):283-92
Acta physiologica (Oxford, England) 2014 Dec;212(4):283-92
Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast.
Seo J, Min SK, Park HR, Kim DH, Kwon MJ, Kim LS, Ju YS
Journal of breast cancer 2014 Dec;17(4):323-31
Journal of breast cancer 2014 Dec;17(4):323-31
Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.
Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167
HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.
He M, Zhang B, Wei X, Wang Z, Fan B, Du P, Zhang Y, Jian W, Chen L, Wang L, Fang H, Li X, Wang PA, Yi F
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
Journal of cellular and molecular medicine 2013 Apr;17(4):531-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 10255-1-AP(HDAC3 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HDAC3 (IP:10255-1-AP, 3ug; Detection:10255-1-AP 1:300) with A431 cells lysate 1200ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10255-1-AP(HDAC3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC3. This antibody recognizes human,mouse,rat antigen. The HDAC3 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
