AGTO-G011E

antibody from Creative Biolabs

Targeting: CD7 GP40, LEU-9, Tp40, TP41

No application information provided.

Antibody Data

Product number

AGTO-G011E

Provider

Creative Biolabs

Product name

Anti-CD7 immunotoxin TH-69 (scFv)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-CD7 scFv to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human CD7, a surface antigen of leukemic T cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating acute Leukemic T Cells.

Reactivity

Human

Host

Mouse