11-7002

antibody from ABEOMICS Inc.
Targeting: DFFA DFF-45, DFF1, DFF45, ICAD
Provider product page for 11-7002

Antibody data

Product number
11-7002 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-ICAD Antibody
Antibody type
Polyclonal
Description
ICAD/DFF45 is an inhibitor of the caspase-activated DNase (CAD, DFF40). DNA fragmentation factor (DFF) consists of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). In proliferating cells CAD or DFF40 forms a complex with ICAD or DFF45. When cells undergo apoptosis, caspase 3 cleaves ICAD at two sites to dissociate the CAD:ICAD complex, allowing CAD to cleave chromosomal DNA. Thus DEF induces the fragmentation of DNA which is a hallmark of apoptosis. ICAD is expressed in brain, blood, skin, spleen, adipose tissue. It has 2 isoforms produced by alternative splicing.
Reactivity
Mouse
Host
Rabbit
Antigen sequence
A partial length recombinant ICAD p
rotein (amino acids 111-331) was us
ed as the immunogen for this antibo
dy.
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
DFFA protein structure - 11-7002 shown in red.