Tissue expression
Cell line expression
Protein structure
GAD2
Glutamate decarboxylase 2GAD65
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Top validated antibodies |
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Invitrogen Antibodies | PA5-21297 | 4 references | Polyclonal |
WB
ICC
IHC
OA |
|
Proteintech Group | 21760-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
antibodies-online | ABIN952422 | 2 references | Polyclonal |
WB
EL
ICC
IHC |
|
Novus Biologicals | NBP1-33284 | 2 references | Polyclonal |
WB
ICC
IHC
|
|
NSJ Bioreagents | RQ5856 | Monoclonal |
WB
ICC
IHC
FC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider