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- Novus Biologicals
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- Goat Polyclonal Osteopontin/OPN Antibody
- Antibody type
- Polyclonal
Submitted references Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5(-)CD44(+) cells.
Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis.
In Vivo Activation and Pro-Fibrotic Function of NF-κB in Fibroblastic Cells During Pulmonary Inflammation and Fibrosis Induced by Carbon Nanotubes.
Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma.
ATRQβ-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms.
Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury.
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
Correlation of OPN gene expression with proliferation and apoptosis of ovarian cancer cells and prognosis of patients.
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System.
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Molecular Fingerprinting of On-Off Direction-Selective Retinal Ganglion Cells Across Species and Relevance to Primate Visual Circuits.
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Osteopontin in the host response to Leishmania amazonensis.
Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension.
Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells.
Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation.
Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis.
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.
H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells.
Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression.
Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice.
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity.
HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.
Multicolor quantitative confocal imaging cytometry.
Cardiac macrophages promote diastolic dysfunction.
Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling.
Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures.
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.
Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.
Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress.
Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway.
Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.
Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing.
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.
The P2X4 receptor is required for neuroprotection via ischemic preconditioning.
Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response.
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
Identification of therapeutic targets for glioblastoma by network analysis.
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice.
Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia.
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Loss of JUNB/AP-1 promotes invasive prostate cancer.
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation.
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone.
Impaired hepatocyte maturation, abnormal expression of biliary transcription factors and liver fibrosis in C/EBPα(Cebpa)-knockout mice.
Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.
An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.
Colony-stimulating factor-1 signaling suppresses renal crystal formation.
PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-β signaling pathways.
Identification of a clonally expanding haematopoietic compartment in bone marrow.
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.
Cellular basis of tissue regeneration by omentum.
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.
The critical role of agrin in the hematopoietic stem cell niche.
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.
Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse.
In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression.
Fibroblast growth factor-2 regulates expression of osteopontin in periodontal ligament cells.
Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets.
Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung.
Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.
Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.
Fu DJ, Wang L, Chouairi FK, Rose IM, Abetov DA, Miller AD, Yamulla RJ, Schimenti JC, Flesken-Nikitin A, Nikitin AY
Nature communications 2020 Jan 3;11(1):84
Nature communications 2020 Jan 3;11(1):84
Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis.
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, Pasek RC, Cereghini S, Morillon L, Guerra C, Couvelard A, Gannon M, Haumaitre C
Cellular and molecular gastroenterology and hepatology 2019;8(3):487-511
Cellular and molecular gastroenterology and hepatology 2019;8(3):487-511
In Vivo Activation and Pro-Fibrotic Function of NF-κB in Fibroblastic Cells During Pulmonary Inflammation and Fibrosis Induced by Carbon Nanotubes.
Dong J, Ma Q
Frontiers in pharmacology 2019;10:1140
Frontiers in pharmacology 2019;10:1140
Survival of Alpha and Intrinsically Photosensitive Retinal Ganglion Cells in NMDA-Induced Neurotoxicity and a Mouse Model of Normal Tension Glaucoma.
Honda S, Namekata K, Kimura A, Guo X, Harada C, Murakami A, Matsuda A, Harada T
Investigative ophthalmology & visual science 2019 Sep 3;60(12):3696-3707
Investigative ophthalmology & visual science 2019 Sep 3;60(12):3696-3707
ATRQβ-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms.
Zhang H, Liao M, Cao M, Qiu Z, Yan X, Zhou Y, Wu H, Wang Y, Zheng J, Ding J, Wang M, Liao Y, Chen X
Journal of the American Heart Association 2019 Sep 17;8(18):e012341
Journal of the American Heart Association 2019 Sep 17;8(18):e012341
Characterization of Matricellular Protein Expression Signatures in Mechanistically Diverse Mouse Models of Kidney Injury.
Feng D, Ngov C, Henley N, Boufaied N, Gerarduzzi C
Scientific reports 2019 Nov 13;9(1):16736
Scientific reports 2019 Nov 13;9(1):16736
Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin.
Wen Y, Wang C, Gu J, Yu C, Wang K, Sun X, Sun Y, Wu H, Tong Y, Xia Q, Kong X
Cellular & molecular immunology 2019 May;16(5):483-494
Cellular & molecular immunology 2019 May;16(5):483-494
Correlation of OPN gene expression with proliferation and apoptosis of ovarian cancer cells and prognosis of patients.
Hu H, Liu Z, Liu C
Oncology letters 2019 Mar;17(3):2788-2794
Oncology letters 2019 Mar;17(3):2788-2794
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
van de Vlekkert D, Demmers J, Nguyen XX, Campos Y, Machado E, Annunziata I, Hu H, Gomero E, Qiu X, Bongiovanni A, Feghali-Bostwick CA, d'Azzo A
Science advances 2019 Jul;5(7):eaav3270
Science advances 2019 Jul;5(7):eaav3270
Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System.
Sayyid ZN, Wang T, Chen L, Jones SM, Cheng AG
Cell reports 2019 Jul 9;28(2):312-324.e4
Cell reports 2019 Jul 9;28(2):312-324.e4
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Pepe-Mooney BJ, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, van Oudenaarden A, Camargo FD
Cell stem cell 2019 Jul 3;25(1):23-38.e8
Cell stem cell 2019 Jul 3;25(1):23-38.e8
Molecular Fingerprinting of On-Off Direction-Selective Retinal Ganglion Cells Across Species and Relevance to Primate Visual Circuits.
Dhande OS, Stafford BK, Franke K, El-Danaf R, Percival KA, Phan AH, Li P, Hansen BJ, Nguyen PL, Berens P, Taylor WR, Callaway E, Euler T, Huberman AD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jan 2;39(1):78-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jan 2;39(1):78-95
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L
Cell reports 2019 Jan 15;26(3):652-669.e6
Cell reports 2019 Jan 15;26(3):652-669.e6
Osteopontin in the host response to Leishmania amazonensis.
Giraud E, Rouault E, Fiette L, Colle JH, Smirlis D, Melanitou E
BMC microbiology 2019 Feb 8;19(1):32
BMC microbiology 2019 Feb 8;19(1):32
Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension.
Caglayan E, Trappiel M, Behringer A, Berghausen EM, Odenthal M, Wellnhofer E, Kappert K
Respiratory research 2019 Feb 27;20(1):42
Respiratory research 2019 Feb 27;20(1):42
Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells.
Wasgewatte Wijesinghe DK, Mackie EJ, Pagel CN
Skeletal muscle 2019 Feb 26;9(1):6
Skeletal muscle 2019 Feb 26;9(1):6
Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation.
Romeo SG, Alawi KM, Rodrigues J, Singh A, Kusumbe AP, Ramasamy SK
Nature cell biology 2019 Apr;21(4):430-441
Nature cell biology 2019 Apr;21(4):430-441
Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis.
Kobori T, Hamasaki S, Kitaura A, Yamazaki Y, Nishinaka T, Niwa A, Nakao S, Wake H, Mori S, Yoshino T, Nishibori M, Takahashi H
Frontiers in immunology 2018;9:334
Frontiers in immunology 2018;9:334
Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte Proliferation.
D'Souza AM, Jiang Y, Cast A, Valanejad L, Wright M, Lewis K, Kumbaji M, Shah S, Smithrud D, Karns R, Shin S, Timchenko N
Cellular and molecular gastroenterology and hepatology 2018;6(3):239-255
Cellular and molecular gastroenterology and hepatology 2018;6(3):239-255
Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.
Falero-Perez J, Song YS, Zhao Y, Teixeira L, Sorenson CM, Sheibani N
PloS one 2018;13(10):e0206756
PloS one 2018;13(10):e0206756
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.
Himburg HA, Termini CM, Schlussel L, Kan J, Li M, Zhao L, Fang T, Sasine JP, Chang VY, Chute JP
Cell stem cell 2018 Sep 6;23(3):370-381.e5
Cell stem cell 2018 Sep 6;23(3):370-381.e5
H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells.
Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W
PLoS biology 2018 Nov;16(11):e2006522
PLoS biology 2018 Nov;16(11):e2006522
Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression.
Lee MN, Hwang HS, Oh SH, Roshanzadeh A, Kim JW, Song JH, Kim ES, Koh JT
Experimental & molecular medicine 2018 Nov 5;50(11):1-16
Experimental & molecular medicine 2018 Nov 5;50(11):1-16
Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.
Liu J, Reggiani JDS, Laboulaye MA, Pandey S, Chen B, Rubenstein JLR, Krishnaswamy A, Sanes JR
Nature neuroscience 2018 May;21(5):659-670
Nature neuroscience 2018 May;21(5):659-670
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Kim KH, Kim SH, Han DH, Jo YS, Lee YH, Lee MS
Scientific reports 2018 May 1;8(1):6789
Scientific reports 2018 May 1;8(1):6789
Type 2 diabetes impairs the ability of skeletal muscle pericytes to augment postischemic neovascularization in db/db mice.
Hayes KL, Messina LM, Schwartz LM, Yan J, Burnside AS, Witkowski S
American journal of physiology. Cell physiology 2018 May 1;314(5):C534-C544
American journal of physiology. Cell physiology 2018 May 1;314(5):C534-C544
Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.
Ding W, Yousefi K, Goncalves S, Goldstein BJ, Sabater AL, Kloosterboer A, Ritter P, Lambert G, Mendez AJ, Shehadeh LA
JCI insight 2018 Mar 22;3(6)
JCI insight 2018 Mar 22;3(6)
Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity.
Zeng Q, Luo X, Han M, Liu W, Li H
EBioMedicine 2018 Jun;32:43-49
EBioMedicine 2018 Jun;32:43-49
HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis.
Hernandez C, Huebener P, Pradere JP, Antoine DJ, Friedman RA, Schwabe RF
The Journal of clinical investigation 2018 Jun 1;128(6):2436-2451
The Journal of clinical investigation 2018 Jun 1;128(6):2436-2451
Multicolor quantitative confocal imaging cytometry.
Coutu DL, Kokkaliaris KD, Kunz L, Schroeder T
Nature methods 2018 Jan;15(1):39-46
Nature methods 2018 Jan;15(1):39-46
Cardiac macrophages promote diastolic dysfunction.
Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M
The Journal of experimental medicine 2018 Feb 5;215(2):423-440
The Journal of experimental medicine 2018 Feb 5;215(2):423-440
Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling.
Kaylan KB, Berg IC, Biehl MJ, Brougham-Cook A, Jain I, Jamil SM, Sargeant LH, Cornell NJ, Raetzman LT, Underhill GH
eLife 2018 Dec 27;7
eLife 2018 Dec 27;7
Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures.
Krieger B, Qiao M, Rousso DL, Sanes JR, Meister M
PloS one 2017;12(7):e0180091
PloS one 2017;12(7):e0180091
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.
Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH
Nature cell biology 2017 Mar;19(3):189-201
Nature cell biology 2017 Mar;19(3):189-201
Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.
Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z
Neuron 2017 Jun 21;94(6):1112-1120.e4
Neuron 2017 Jun 21;94(6):1112-1120.e4
Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin, TGF-β1, IL-13 and oxidative stress.
de Souza VCA, Pereira TA, Teixeira VW, Carvalho H, de Castro MCAB, D'assunção CG, de Barros AF, Carvalho CL, de Lorena VMB, Costa VMA, Teixeira ÁAC, Figueiredo RCBQ, de Oliveira SA
World journal of gastroenterology 2017 Jul 28;23(28):5146-5157
World journal of gastroenterology 2017 Jul 28;23(28):5146-5157
Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway.
Chen CH, Sue YM, Cheng CY, Chen YC, Liu CT, Hsu YH, Hwang PA, Huang NJ, Chen TH
Scientific reports 2017 Jan 18;7:40183
Scientific reports 2017 Jan 18;7:40183
Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo.
Yuan G, Chen L, Feng J, Yang G, Ni Q, Xu X, Wan C, Lindsey M, Donly KJ, MacDougall M, Chen Z, Chen S
Scientific reports 2017 Feb 14;7:42449
Scientific reports 2017 Feb 14;7:42449
Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing.
Hosaka K, Rojas K, Fazal HZ, Schneider MB, Shores J, Federico V, McCord M, Lin L, Hoh B
Stroke 2017 Apr;48(4):1052-1060
Stroke 2017 Apr;48(4):1052-1060
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H
The EMBO journal 2017 Apr 3;36(7):840-853
The EMBO journal 2017 Apr 3;36(7):840-853
Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.
Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V
Cancer research 2016 May 15;76(10):3045-56
Cancer research 2016 May 15;76(10):3045-56
The P2X4 receptor is required for neuroprotection via ischemic preconditioning.
Ozaki T, Muramatsu R, Sasai M, Yamamoto M, Kubota Y, Fujinaka T, Yoshimine T, Yamashita T
Scientific reports 2016 May 13;6:25893
Scientific reports 2016 May 13;6:25893
Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response.
Zhao K, Zhang M, Zhang L, Wang P, Song G, Liu B, Wu H, Yin Z, Gao C
Scientific reports 2016 Mar 30;6:23771
Scientific reports 2016 Mar 30;6:23771
Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.
Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H
Scientific reports 2016 Jun 6;6:27354
Scientific reports 2016 Jun 6;6:27354
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K
The Journal of clinical investigation 2016 Jun 1;126(6):2151-66
The Journal of clinical investigation 2016 Jun 1;126(6):2151-66
Identification of therapeutic targets for glioblastoma by network analysis.
Friedmann-Morvinski D, Bhargava V, Gupta S, Verma IM, Subramaniam S
Oncogene 2016 Feb 4;35(5):608-20
Oncogene 2016 Feb 4;35(5):608-20
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL
JCI insight 2016 Dec 22;1(21):e90341
JCI insight 2016 Dec 22;1(21):e90341
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF
The Journal of clinical investigation 2015 Oct 1;125(10):3891-903
The Journal of clinical investigation 2015 Oct 1;125(10):3891-903
Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice.
Park JW, Lee SH, Go du M, Kim HK, Kwon HJ, Kim DY
Laboratory investigation; a journal of technical methods and pathology 2015 Jun;95(6):660-71
Laboratory investigation; a journal of technical methods and pathology 2015 Jun;95(6):660-71
Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia.
Inoue M, Shinohara ML
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 15;194(12):5595-8
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 15;194(12):5595-8
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, Hjerling-Leffler J, Haeggström J, Kharchenko O, Kharchenko PV, Linnarsson S, Ernfors P
Nature neuroscience 2015 Jan;18(1):145-53
Nature neuroscience 2015 Jan;18(1):145-53
Loss of JUNB/AP-1 promotes invasive prostate cancer.
Thomsen MK, Bakiri L, Hasenfuss SC, Wu H, Morente M, Wagner EF
Cell death and differentiation 2015 Apr;22(4):574-82
Cell death and differentiation 2015 Apr;22(4):574-82
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation.
Kourepini E, Aggelakopoulou M, Alissafi T, Paschalidis N, Simoes DC, Panoutsakopoulou V
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 4;111(9):E856-65
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 4;111(9):E856-65
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Ramasamy SK, Kusumbe AP, Wang L, Adams RH
Nature 2014 Mar 20;507(7492):376-380
Nature 2014 Mar 20;507(7492):376-380
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone.
Kusumbe AP, Ramasamy SK, Adams RH
Nature 2014 Mar 20;507(7492):323-328
Nature 2014 Mar 20;507(7492):323-328
Impaired hepatocyte maturation, abnormal expression of biliary transcription factors and liver fibrosis in C/EBPα(Cebpa)-knockout mice.
Akai Y, Oitate T, Koike T, Shiojiri N
Histology and histopathology 2014 Jan;29(1):107-25
Histology and histopathology 2014 Jan;29(1):107-25
Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.
Lyle AN, Remus EW, Fan AE, Lassègue B, Walter GA, Kiyosue A, Griendling KK, Taylor WR
The Journal of biological chemistry 2014 Jan 3;289(1):275-85
The Journal of biological chemistry 2014 Jan 3;289(1):275-85
An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.
Chen Q, Shou P, Zhang L, Xu C, Zheng C, Han Y, Li W, Huang Y, Zhang X, Shao C, Roberts AI, Rabson AB, Ren G, Zhang Y, Wang Y, Denhardt DT, Shi Y
Stem cells (Dayton, Ohio) 2014 Feb;32(2):327-37
Stem cells (Dayton, Ohio) 2014 Feb;32(2):327-37
Colony-stimulating factor-1 signaling suppresses renal crystal formation.
Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1680-97
Journal of the American Society of Nephrology : JASN 2014 Aug;25(8):1680-97
PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z
Circulation research 2014 Aug 15;115(5):504-17
Circulation research 2014 Aug 15;115(5):504-17
Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-β signaling pathways.
Park S, Dimaio TA, Liu W, Wang S, Sorenson CM, Sheibani N
Journal of cell science 2013 Mar 15;126(Pt 6):1392-405
Journal of cell science 2013 Mar 15;126(Pt 6):1392-405
Identification of a clonally expanding haematopoietic compartment in bone marrow.
Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH
The EMBO journal 2013 Jan 23;32(2):219-30
The EMBO journal 2013 Jan 23;32(2):219-30
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.
Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE
Journal of immunology (Baltimore, Md. : 1950) 2013 Feb 1;190(3):1094-102
Journal of immunology (Baltimore, Md. : 1950) 2013 Feb 1;190(3):1094-102
Cellular basis of tissue regeneration by omentum.
Shah S, Lowery E, Braun RK, Martin A, Huang N, Medina M, Sethupathi P, Seki Y, Takami M, Byrne K, Wigfield C, Love RB, Iwashima M
PloS one 2012;7(6):e38368
PloS one 2012;7(6):e38368
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM
Kidney international 2012 Dec;82(12):1261-70
Kidney international 2012 Dec;82(12):1261-70
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.
Sabbagh Y, Graciolli FG, O'Brien S, Tang W, dos Reis LM, Ryan S, Phillips L, Boulanger J, Song W, Bracken C, Liu S, Ledbetter S, Dechow P, Canziani ME, Carvalho AB, Jorgetti V, Moyses RM, Schiavi SC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Aug;27(8):1757-72
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 Aug;27(8):1757-72
The critical role of agrin in the hematopoietic stem cell niche.
Mazzon C, Anselmo A, Cibella J, Soldani C, Destro A, Kim N, Roncalli M, Burden SJ, Dustin ML, Sarukhan A, Viola A
Blood 2011 Sep 8;118(10):2733-42
Blood 2011 Sep 8;118(10):2733-42
Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease.
Schneider DJ, Lindsay JC, Zhou Y, Molina JG, Blackburn MR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jan;24(1):70-80
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jan;24(1):70-80
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Säemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
Diabetes 2010 Apr;59(4):935-46
Diabetes 2010 Apr;59(4):935-46
Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin.
El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM
Kidney international 2009 Jun;75(12):1297-1307
Kidney international 2009 Jun;75(12):1297-1307
Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse.
Takanashi M, Oikawa K, Sudo K, Tanaka M, Fujita K, Ishikawa A, Nakae S, Kaspar RL, Matsuzaki M, Kudo M, Kuroda M
Gene therapy 2009 Aug;16(8):982-9
Gene therapy 2009 Aug;16(8):982-9
In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression.
Marcondes MC, Poling M, Watry DD, Hall D, Fox HS
Cellular immunology 2008;254(1):56-62
Cellular immunology 2008;254(1):56-62
Fibroblast growth factor-2 regulates expression of osteopontin in periodontal ligament cells.
Terashima Y, Shimabukuro Y, Terashima H, Ozasa M, Terakura M, Ikezawa K, Hashikawa T, Takedachi M, Oohara H, Yamada S, Murakami S
Journal of cellular physiology 2008 Sep;216(3):640-50
Journal of cellular physiology 2008 Sep;216(3):640-50
Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.
Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS
Journal of virology 2008 May;82(10):4946-54
Journal of virology 2008 May;82(10):4946-54
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Murugaiyan G, Mittal A, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):7480-8
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):7480-8
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Murugaiyan G, Mittal A, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):7480-8
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):7480-8
Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets.
Xanthou G, Alissafi T, Semitekolou M, Simoes DC, Economidou E, Gaga M, Lambrecht BN, Lloyd CM, Panoutsakopoulou V
Nature medicine 2007 May;13(5):570-8
Nature medicine 2007 May;13(5):570-8
Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung.
André E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, Lentner B, Reinhard C, Schulz H, Wjst M
The European respiratory journal 2006 Aug;28(2):275-85
The European respiratory journal 2006 Aug;28(2):275-85
Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.
Hamazaki T, Oka M, Yamanaka S, Terada N
Journal of cell science 2004 Nov 1;117(Pt 23):5681-6
Journal of cell science 2004 Nov 1;117(Pt 23):5681-6
Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.
Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C
Arthritis and rheumatism 2004 Aug;50(8):2685-94
Arthritis and rheumatism 2004 Aug;50(8):2685-94
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Osteopontin/OPN in Mouse Thymus. Osteopontin/OPN was detected in perfusion fixed frozen sections of mouse thymus using Mouse Osteopontin/OPN Antigen Affinity-purified Polyclonal Antibody (Catalog # AF808) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cell Adhesion Mediated by Osteopontin/OPN and Neutralization by Mouse Osteopontin/OPN Antibody. Recombinant Mouse Osteopontin/OPN (Catalog # 441-OP), immobilized onto a microplate, supports the adhesion of the HEK293 human embryonic kidney cell line in a dose-dependent manner (orange line). Adhesion elicited by Recombinant Mouse Osteopontin/OPN (2 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Osteopontin/OPN Antigen Affinity-purified Polyclonal Antibody (Catalog # AF808). The ND50 is typically 1-3 µg/mL.
