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Western blot
Immunoelectron microscopyAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Immunoelectron microscopy [1]
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- Product number
- 678402 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#678402, RRID:AB_2565903
- Product name
- Purified anti-HDAC1
- Antibody type
- Monoclonal
- Antigen
- Synthetic human HDAC1 peptide (467-482 a.a.) conjugated to KLH.
- Description
- HDAC1 (histone deacetylase 1) is a 65 kD member of the Class I histone deacetylase family, which is similar to the yeast RPD3 protein. This nuclear protein operates in concert with histone acetyltransferases to control core histone acetylation in highly conserved lysine residues. HDAC activity has been associated with transcriptional repression and nucleosomal condensation. HDAC1 deacetylates RELA at residue K310, which results in the inhibition of NF-κB activity. HDAC1 has been suggested to participate in the regulation of eukaryotic gene expression and cell cycle progression. HDAC1-deficient mice were shown to be embryonic lethal, suggesting that HDAC1 plays a crucial role during embryonic development.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 1A6C37
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Total cell lysate from Jurkat cells (lane 1) and mouse thymocytes (lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-HDAC1 (clone 1A6C37) antibody. Proteins were visualized using an anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection.
- Conjugate
- Unconjugated
