Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- GTX109683 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX109683, RRID:AB_1949720
- Product name
- Bax antibody [N1N2], N-term
- Antibody type
- Polyclonal
- Reactivity
- Human, Rat
- Host
- Rabbit
Submitted references Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling.
Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model.
Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats.
Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.
Bushenshugan Formula Attenuates the Development of Lung Cancer by Inhibiting Epithelial-Mesenchymal Transition.
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells.
Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells.
Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.
Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling.
Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway.
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.
MicroRNA-target cross-talks: Key players in glioblastoma multiforme.
Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line.
Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ.
Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model.
Extracellular signal-regulated kinase 8-mediated NF-κB activation increases sensitivity of human lung cancer cells to arsenic trioxide.
Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.
DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.
High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling.
The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.
Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells.
Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene.
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma.
Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells.
Importance of IL-6, MMP-1, IGF-1, and BAX Levels in Lumbar Herniated Disks and Posterior Longitudinal Ligament in Patients with Sciatic Pain.
15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies.
Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines.
Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells
A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury.
Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.
Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.
Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells.
Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells.
Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.
Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.
p53 in trichostatin A induced C6 glioma cell death.
Tang YJ, Li K, Yang CL, Huang K, Zhou J, Shi Y, Xie KG, Liu J
Drug design, development and therapy 2019;13:513-521
Drug design, development and therapy 2019;13:513-521
Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model.
Yu H, Wang L, Zhang H, Wei W, Chen Y, Tang W, Wan Z
Microcirculation (New York, N.Y. : 1994) 2019 Feb 23;
Microcirculation (New York, N.Y. : 1994) 2019 Feb 23;
Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats.
Abdel-Daim MM, Dessouki AA, Abdel-Rahman HG, Eltaysh R, Alkahtani S
The Science of the total environment 2019 Feb 10;650(Pt 2):2063-2073
The Science of the total environment 2019 Feb 10;650(Pt 2):2063-2073
Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.
Lee CW, Chi MC, Chang TM, Liu JF
Journal of cellular physiology 2019 Aug;234(8):13157-13168
Journal of cellular physiology 2019 Aug;234(8):13157-13168
Bushenshugan Formula Attenuates the Development of Lung Cancer by Inhibiting Epithelial-Mesenchymal Transition.
Fan Z, Xue W, Dou M, Li L, Lu J, Ma B, Deng X, Zhang M, Zhai Y, Wang S, Zhao J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(5):1977-1988
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(5):1977-1988
Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors.
Briest F, Grass I, Sedding D, Möbs M, Christen F, Benecke J, Fuchs K, Mende S, Kaemmerer D, Sänger J, Kunze A, Geisler C, Freitag H, Lewens F, Worpenberg L, Iwaszkiewicz S, Siegmund B, Walther W, Hummel M, Grabowski P
Neuroendocrinology 2018;107(1):1-23
Neuroendocrinology 2018;107(1):1-23
Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells.
Lee CF, Chiang NN, Lu YH, Huang YS, Yang JS, Tsai SC, Lu CC, Chen FA
BioMedicine 2018 Sep;8(3):15
BioMedicine 2018 Sep;8(3):15
Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells.
Ibañez-Cabellos JS, Aguado C, Pérez-Cremades D, García-Giménez JL, Bueno-Betí C, García-López EM, Romá-Mateo C, Novella S, Hermenegildo C, Pallardó FV
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3234-3246
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3234-3246
Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.
Günes-Bayir A, Kocyigit A, Güler EM, Bilgin MG, Ergün İS, Dadak A
Molecular and cellular biochemistry 2018 Nov;448(1-2):237-249
Molecular and cellular biochemistry 2018 Nov;448(1-2):237-249
Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling.
Chang HP, Lu CC, Chiang JH, Tsai FJ, Juan YN, Tsao JW, Chiu HY, Yang JS
International journal of oncology 2018 May;52(5):1504-1514
International journal of oncology 2018 May;52(5):1504-1514
Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway.
Lin SC, Chu PY, Liao WT, Wu MY, Tsui KH, Lin LT, Huang CH, Chen LL, Li CJ
Oncology reports 2018 Feb;39(2):703-710
Oncology reports 2018 Feb;39(2):703-710
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Tu HJ, Lin YJ, Chao MW, Sung TY, Wu YW, Chen YY, Lin MH, Liou JP, Pan SL, Yang CR
Clinical epigenetics 2018 Dec 29;10(1):162
Clinical epigenetics 2018 Dec 29;10(1):162
Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects.
Azmy MS, Menze ET, El-Naga RN, Tadros MG
Molecular neurobiology 2018 Aug;55(8):6572-6588
Molecular neurobiology 2018 Aug;55(8):6572-6588
MicroRNA-target cross-talks: Key players in glioblastoma multiforme.
Toraih EA, Aly NM, Abdallah HY, Al-Qahtani SA, Shaalan AA, Hussein MH, Fawzy MS
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Nov;39(11):1010428317726842
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Nov;39(11):1010428317726842
Isoliquiritigenin pretreatment attenuates cisplatin induced proximal tubular cells (LLC-PK1) death and enhances the toxicity induced by this drug in bladder cancer T24 cell line.
Patricia Moreno-Londoño A, Bello-Alvarez C, Pedraza-Chaverri J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Nov;109(Pt 1):143-154
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Nov;109(Pt 1):143-154
Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ.
Lee WY, Chen PC, Wu WS, Wu HC, Lan CH, Huang YH, Cheng CH, Chen KC, Lin CW
International journal of cancer 2017 Nov 1;141(9):1921-1931
International journal of cancer 2017 Nov 1;141(9):1921-1931
Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model.
Li J, Luo H, Dong X, Liu Q, Wu C, Zhang T, Hu X, Zhang Y, Song B, Li L
Stem cell research & therapy 2017 May 8;8(1):107
Stem cell research & therapy 2017 May 8;8(1):107
Extracellular signal-regulated kinase 8-mediated NF-κB activation increases sensitivity of human lung cancer cells to arsenic trioxide.
Wu DD, Lau ATY, Yu FY, Cai NL, Dai LJ, Ok Kim M, Jin DY, Xu YM
Oncotarget 2017 Jul 25;8(30):49144-49155
Oncotarget 2017 Jul 25;8(30):49144-49155
Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.
Hsu SW, Chang TC, Wu YK, Lin KT, Shi LS, Lee SY
BMC complementary and alternative medicine 2017 Jan 7;17(1):29
BMC complementary and alternative medicine 2017 Jan 7;17(1):29
DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.
Tsui KH, Wang PH, Lin LT, Li CJ
Reproduction (Cambridge, England) 2017 Aug;154(2):101-110
Reproduction (Cambridge, England) 2017 Aug;154(2):101-110
High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling.
Fu X, Xie FN, Dong P, Li QC, Yu GY, Xiao R
PloS one 2016;11(2):e0148819
PloS one 2016;11(2):e0148819
The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.
Chen PH, Chang CK, Shih CM, Cheng CH, Lin CW, Lee CC, Liu AJ, Ho KH, Chen KC
Neuropharmacology 2016 Nov;110(Pt A):362-375
Neuropharmacology 2016 Nov;110(Pt A):362-375
Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells.
Constantinescu AA, Abbas M, Kassem M, Gleizes C, Kreutter G, Schini-Kerth V, Mitrea IL, Toti F, Kessler L
Molecular and cellular biochemistry 2016 Jul;418(1-2):91-102
Molecular and cellular biochemistry 2016 Jul;418(1-2):91-102
Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Chen MF, Huang SJ, Huang CC, Liu PS, Lin KI, Liu CW, Hsieh WC, Shiu LY, Chen CH
BMC cancer 2016 Jul 26;16:532
BMC cancer 2016 Jul 26;16:532
Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
Xu YM, Wu DD, Zheng W, Yu FY, Yang F, Yao Y, Zhou Y, Ching YP, Lau AT
Oncotarget 2016 Feb 2;7(5):6146-58
Oncotarget 2016 Feb 2;7(5):6146-58
Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene.
Huang RF, Wei YJ, Inbaraj BS, Chen BH
International journal of nanomedicine 2015;10:2823-46
International journal of nanomedicine 2015;10:2823-46
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Lee WY, Lee WT, Cheng CH, Chen KC, Chou CM, Chung CH, Sun MS, Cheng HW, Ho MN, Lin CW
Oncotarget 2015 Sep 29;6(29):27580-95
Oncotarget 2015 Sep 29;6(29):27580-95
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Lee WY, Lee WT, Cheng CH, Chen KC, Chou CM, Chung CH, Sun MS, Cheng HW, Ho MN, Lin CW
Oncotarget 2015 Sep 29;6(29):27580-95
Oncotarget 2015 Sep 29;6(29):27580-95
PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma.
Lin ST, May EW, Chang JF, Hu RY, Wang LH, Chan HL
Cellular and molecular life sciences : CMLS 2015 Jun;72(12):2395-409
Cellular and molecular life sciences : CMLS 2015 Jun;72(12):2395-409
Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells.
Luciani-Torres MG, Moore DH, Goodson WH 3rd, Dairkee SH
Carcinogenesis 2015 Jan;36(1):168-76
Carcinogenesis 2015 Jan;36(1):168-76
Importance of IL-6, MMP-1, IGF-1, and BAX Levels in Lumbar Herniated Disks and Posterior Longitudinal Ligament in Patients with Sciatic Pain.
Dagistan Y, Cukur S, Dagistan E, Gezici AR
World neurosurgery 2015 Dec;84(6):1739-46
World neurosurgery 2015 Dec;84(6):1739-46
15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies.
Liu JJ, Wu HH, Chen TH, Leung W, Liang YC
International journal of molecular sciences 2015 Aug 17;16(8):19387-400
International journal of molecular sciences 2015 Aug 17;16(8):19387-400
Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Li CJ, Sun LY, Pang CY
Scientific reports 2015 Apr 24;5:9819
Scientific reports 2015 Apr 24;5:9819
Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines.
Lee JG, Wang YS, Chou CC
Toxicology in vitro : an international journal published in association with BIBRA 2014 Jun;28(4):562-70
Toxicology in vitro : an international journal published in association with BIBRA 2014 Jun;28(4):562-70
Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells
Abdi J, Garssen J, Faber J, Redegeld F
The Journal of Nutritional Biochemistry 2014 December;25(12):1254-1262
The Journal of Nutritional Biochemistry 2014 December;25(12):1254-1262
A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, Gonzalez-Alvarez I, García-Giménez JL, Díaz Cabañas MJ, Bermejo M, Corma A
European journal of medicinal chemistry 2014 Aug 18;83:366-73
European journal of medicinal chemistry 2014 Aug 18;83:366-73
Protective role of AMP-activated protein kinase-evoked autophagy on an in vitro model of ischemia/reperfusion-induced renal tubular cell injury.
Wang LT, Chen BL, Wu CT, Huang KH, Chiang CK, Hwa Liu S
PloS one 2013;8(11):e79814
PloS one 2013;8(11):e79814
Protective roles of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in dengue virus infection of human lung epithelial cells.
Hsu YL, Shi SF, Wu WL, Ho LJ, Lai JH
PloS one 2013;8(11):e79518
PloS one 2013;8(11):e79518
Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.
Chen YW, Chou HC, Lin ST, Chen YH, Chang YJ, Chen L, Chan HL
Evidence-based complementary and alternative medicine : eCAM 2013;2013:364519
Evidence-based complementary and alternative medicine : eCAM 2013;2013:364519
Stimulation of Toll-like receptor-1/2 combined with Velcade increases cytotoxicity to human multiple myeloma cells.
Abdi J, Mutis T, Garssen J, Redegeld F
Blood cancer journal 2013 May 31;3:e119
Blood cancer journal 2013 May 31;3:e119
Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells.
Chen JH, Yang CH, Wang YS, Lee JG, Cheng CH, Chou CC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Jan;51:446-52
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Jan;51:446-52
Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY
Evidence-based complementary and alternative medicine : eCAM 2012;2012:261971
Evidence-based complementary and alternative medicine : eCAM 2012;2012:261971
Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.
Li CJ, Chu CY, Huang LH, Wang MH, Sheu LF, Yeh JI, Hsu HY
Cancer letters 2012 Jun 28;319(2):203-213
Cancer letters 2012 Jun 28;319(2):203-213
Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.
Liu CH, Chen CY, Huang AM, Li JH
Journal of ethnopharmacology 2011 Sep 1;137(1):503-11
Journal of ethnopharmacology 2011 Sep 1;137(1):503-11
p53 in trichostatin A induced C6 glioma cell death.
Hsu YF, Sheu JR, Hsiao G, Lin CH, Chang TH, Chiu PT, Wang CY, Hsu MJ
Biochimica et biophysica acta 2011 May;1810(5):504-13
Biochimica et biophysica acta 2011 May;1810(5):504-13
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Sample(30 ?g whole cell lysate)A:Hep G2 (GTX27900)12% SDS PAGEGTX109683 diluted at 1:1000The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Bax antibody [N1N2], N-term detects Bax protein at cytoplasm, nucleus and mitochondria by immunofluorescent analysis.Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: Bax protein stained by Bax antibody [N1N2], N-term (GTX109683) diluted at 1:400.Blue: Hoechst 33342 staining.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Bax antibody [N1N2], N-term immunoprecipitates BCL2-associated X protein in IP experiments.IP samples: MCF-7 whole cell extractA. Control with 4 £gg of preimmune Rabbit IgGB. Immunoprecipitation of BCL2-associated X protein by 4 £gg Bax antibody [N1N2], N-term (GTX109683)15 % SDS-PAGEThe immunoprecipitated BCL2-associated X protein was detected by Bax antibody [N1N2], N-term (GTX109683) diluted at 1:500.[EasyBlot anti-rabbit IgG (GTX221666-01) was used as a secondary reagent]
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Bax antibody [N1N2], N-term detects Bax protein at cytoplasm on human lung carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human lung carcinoma. Bax antibody [N1N2], N-term (GTX109683) diluted at 1:500.