625101

antibody from BioLegend
Targeting: BAX BCL2L4
Provider product page for 625101
Western blot
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
625101 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#625101, RRID:AB_315997
Product name
Purified anti-Bax
Antibody type
Polyclonal
Antigen
Peptide-KLH, N-terminal
Description
Bax is a 21 kD pro-apoptotic protien known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, the ovary, and in the lymph node. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers. The Poly6251 antibody has been reported to be useful for Western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Bax protein.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Vial size
50 µl
Storage
The antibody solution should be stored undiluted at 4°C. DO NOT FREEZE.
BAX protein structure - 625101 shown in red.