DPABH-23406

antibody from Creative Diagnostics
Targeting: ERCC1 RAD10
Provider product page for DPABH-23406
Western blot
ELISA
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
DPABH-23406 - Provider product page
Provider
Creative Diagnostics
Proper citation
Creative Diagnostics Cat#DPABH-23406, RRID:AB_2518089
Product name
Rabbit Anti-Human ERCC1 Polyclonal antibody
Antibody type
Polyclonal
Description
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5 incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 uL
ERCC1 protein structure - DPABH-23406 shown in red.