abx015921

antibody from Abbexa

Targeting: MAPK8 JNK, JNK1, PRKM8, SAPK1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

abx015921

Provider

Abbexa

Product name

Mitogen Activated Protein Kinase 8 / JNK1 (MAPK8) Antibody

Antibody type

Monoclonal

Description

The protein encoded by this gene is a member of the MAP kinase family.MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli.The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis.This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

1 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.