690602

antibody from BioLegend
Targeting: NFATC3 NFAT4, NFATX
Provider product page for 690602

Antibody data

Product number
690602 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#690602, RRID:AB_2629823
Product name
Purified anti-NFATC3
Antibody type
Monoclonal
Description
Nuclear factor of activated T cells C3 (NFATC3), also known as NFAT4 or NFATx, is a member of the NFAT family of transcription factors. Several NFATC3 variants generated by alternative splicing were identified. NFATC3 plays an important role in the regulation of T cell activation-related gene expression, especially in the induction of IL-2.  NFATC3 is expressed in immune cells, such as double positive (DP) thymocytes, mature CD4+ T cells, and mast cells. It is also found in non-immune cells such as smooth muscle and Schwann cells. In the resting T cells, NFATC3 is located in the cytoplasm and is phosphorylated. Upon T cell activation by TCR stimulation, the increase of intracellular Ca2+ induces NFATC3 dephosphorylation via calcineurin. Dephosphorylated NFATC3 exposes the nuclear localization signal and is subsequently translocated from the cytosol to the nucleus. Through the highly conserved Rel-like binding domain, NFATC3 associates with specific consensus DNA sequences and regulates gene expression.
Reactivity
Human, Mouse
Host
Rat
Conjugate
Unconjugated
Antibody clone number
W15221A
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
NFATC3 protein structure - 690602 shown in red.