BS4860

antibody from Bioworld Technology, Inc
Targeting: PIN1 dod
Provider product page for BS4860
Western blot
Immunohistochemistry

Antibody data

Product number
BS4860 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PIN1 (phospho S16) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human PIN1 around the phosphorylation site of Serine 16.
Description
NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2 and Nek3. High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Pin1 was originally identified as a NIMA-interacting protein. Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase), which specifically binds to phosphoserine-proline or phosphothreonine-proline bonds in mitotic phosphoproteins. While previously identified PPIases have been shown to be involved in protein folding, assembly and transport, Pin1 is the first PPIase to be identified as a required protein for cell viability.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PIN1 protein structure - BS4860 shown in red.