Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 21218-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21218-1-AP, RRID:AB_10693633
- Product name
- RXRA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RXRA antibody (Cat. #21218-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice.
GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.
Comprehensive characterization of protein-protein interactions perturbed by disease mutations.
Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.
Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway.
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway.
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis.
Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo.
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.
Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.
Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Activation of RAS/ERK alone is insufficient to inhibit RXRα function and deplete retinoic acid in hepatocytes.
Lin Y, Wang S, Gao L, Zhou Z, Yang Z, Lin J, Ren S, Xing H, Wu B
Theranostics 2021;11(1):426-444
Theranostics 2021;11(1):426-444
GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.
Juin SK, Pushpakumar S, Sen U
Biomolecules 2021 Oct 7;11(10)
Biomolecules 2021 Oct 7;11(10)
Comprehensive characterization of protein-protein interactions perturbed by disease mutations.
Cheng F, Zhao J, Wang Y, Lu W, Liu Z, Zhou Y, Martin WR, Wang R, Huang J, Hao T, Yue H, Ma J, Hou Y, Castrillon JA, Fang J, Lathia JD, Keri RA, Lightstone FC, Antman EM, Rabadan R, Hill DE, Eng C, Vidal M, Loscalzo J
Nature genetics 2021 Mar;53(3):342-353
Nature genetics 2021 Mar;53(3):342-353
Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.
Chen X, Wang L, Yu X, Wang S, Zhang J
The international journal of biochemistry & cell biology 2021 Aug;137:106027
The international journal of biochemistry & cell biology 2021 Aug;137:106027
Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway.
Qiu L, Ma Y, Chen X, Zhou L, Zhang H, Zhong G, Zhang L, Tang J
Journal of translational medicine 2021 Aug 10;19(1):344
Journal of translational medicine 2021 Aug 10;19(1):344
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway.
Xiang S, Chen K, Xu L, Wang T, Guo C
Drug design, development and therapy 2020;14:129-143
Drug design, development and therapy 2020;14:129-143
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.
Gelfand CA, Sakurai R, Wang Y, Liu Y, Segal R, Rehan VK
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
American journal of physiology. Lung cellular and molecular physiology 2020 Sep 1;319(3):L576-L584
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
Wang L, Cheng CM, Qin J, Xu M, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu HE, Tsai SY, Tsai MJ
Science advances 2020 May;6(18):eaaz8031
Science advances 2020 May;6(18):eaaz8031
High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.
Xu L, Xia H, Ni D, Hu Y, Liu J, Qin Y, Zhou Q, Yi Q, Xie Y
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis.
Kataoka H, Mori T, Okimura H, Matsushima H, Ito F, Koshiba A, Tanaka Y, Akiyama K, Maeda E, Sugahara T, Tarumi Y, Kusuki I, Khan KN, Kitawaki J
Human reproduction (Oxford, England) 2019 Jun 4;34(6):1019-1029
Human reproduction (Oxford, England) 2019 Jun 4;34(6):1019-1029
Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo.
Wang F, Wang H, Wu Y, Wang L, Zhang L, Ye X, Peng D, Chen W
Drug metabolism and disposition: the biological fate of chemicals 2019 Aug;47(8):785-793
Drug metabolism and disposition: the biological fate of chemicals 2019 Aug;47(8):785-793
Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C
Neurobiology of disease 2018 Sep;117:114-124
Neurobiology of disease 2018 Sep;117:114-124
LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.
Tang J, Zhong G, Zhang H, Yu B, Wei F, Luo L, Kang Y, Wu J, Jiang J, Li Y, Wu S, Jia Y, Liang X, Bi A
Cell death & disease 2018 Dec 5;9(12):1167
Cell death & disease 2018 Dec 5;9(12):1167
Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.
Lu C, Xu W, Zheng S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1-10
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:1-10
Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells.
Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S
International immunopharmacology 2017 Aug;49:203-211
International immunopharmacology 2017 Aug;49:203-211
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
Activation of RAS/ERK alone is insufficient to inhibit RXRα function and deplete retinoic acid in hepatocytes.
Wang AG, Song YN, Chen J, Li HL, Dong JY, Cui HP, Yao L, Li XF, Gao WT, Qiu ZW, Wang FJ, Wang JY
Biochemical and biophysical research communications 2014 Sep 26;452(3):801-7
Biochemical and biophysical research communications 2014 Sep 26;452(3):801-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 21218-1-AP(RXRA antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using RXRA antibody 21218-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 21218-1-AP(RXRA antibody) at dilution of 1:200 (under 10x lens)
- Sample type
- tissue