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antibody from Novus Biologicals
Targeting: CCL21
6Ckine, CKb9, ECL, exodus-2, SCYA21, SLC, TCA4
Western blot
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF366 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal CCL21/6Ckine Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human CCL21/6Ckine in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse (rm) CCL21/6Ckine is observed and less than 5% cross-reactivity with recombinant human (rh) Fractalkine, rhTeck, rhMCP-3, rmCRG-2, rhVIC, and rmVIC is observed.
- Reactivity
- Human
- Host
- Goat
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Inhaled TLR9 Agonist Renders Lung Tumors Permissive to PD-1 Blockade by Promoting Optimal CD4+ and CD8+ T-cell Interplay.
An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis.
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells.
CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.
Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, alpha4beta1 and LFA-1.
Gallotta M, Assi H, Degagné É, Kannan SK, Coffman RL, Guiducci C
Cancer research 2018 Sep 1;78(17):4943-4956
Cancer research 2018 Sep 1;78(17):4943-4956
An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.
Rump L, Mattey DL, Kehoe O, Middleton J
Cytokine 2017 Sep;97:133-140
Cytokine 2017 Sep;97:133-140
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Pinto S, Martínez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C, Callaghan RC
BMC cancer 2014 Feb 22;14:118
BMC cancer 2014 Feb 22;14:118
Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis.
Edwards KR, Goyal J, Plavina T, Czerkowicz J, Goelz S, Ranger A, Cadavid D, Browning JL
PloS one 2013;8(11):e81007
PloS one 2013;8(11):e81007
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Johnson LA, Jackson DG
International immunology 2010 Oct;22(10):839-49
International immunology 2010 Oct;22(10):839-49
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia.
Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E, Shachar I, Dartevelle P, de Rosbo NK, Le Panse R
Annals of neurology 2009 Oct;66(4):521-31
Annals of neurology 2009 Oct;66(4):521-31
Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells.
Wick N, Haluza D, Gurnhofer E, Raab I, Kasimir MT, Prinz M, Steiner CW, Reinisch C, Howorka A, Giovanoli P, Buchsbaum S, Krieger S, Tschachler E, Petzelbauer P, Kerjaschki D
The American journal of pathology 2008 Oct;173(4):1202-9
The American journal of pathology 2008 Oct;173(4):1202-9
CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S
European journal of immunology 2008 Nov;38(11):3050-9
European journal of immunology 2008 Nov;38(11):3050-9
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA
Cancer cell 2007 Jun;11(6):526-38
Cancer cell 2007 Jun;11(6):526-38
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Marchal-Sommé J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Journal of immunology (Baltimore, Md. : 1950) 2006 May 15;176(10):5735-9
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7665-72
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7665-72
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7665-72
Journal of immunology (Baltimore, Md. : 1950) 2006 Dec 1;177(11):7665-72
Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.
Humphreys TL, Baldridge LA, Billings SD, Campbell JJ, Spinola SM
Infection and immunity 2005 Jul;73(7):3896-902
Infection and immunity 2005 Jul;73(7):3896-902
Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, alpha4beta1 and LFA-1.
Sinha RK, Mage RG
Developmental and comparative immunology 2004 Jun;28(7-8):829-41
Developmental and comparative immunology 2004 Jun;28(7-8):829-41
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Chemotaxis Induced by CCL21/6Ckine and Neutralization by Human CCL21/6Ckine Antibody. Chemotaxis Induced by CCL21/6Ckine and Neutralization by Human CCL21/6Ckine Antibody.
