FNab01173

antibody from FineTest Biotech

Targeting: CACNA1S CACNL1A3, Cav1.1, HOKPP, hypoPP, MHS5

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

FNab01173

Provider

FineTest Biotech

Product name

CACNA1S antibody

Antibody type

Polyclonal

Antigen

Recombinant protein fragment

Description

Voltage-sensitive calcium channels(VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting(L-type) calcium channels belong to the 'high-voltage activated'(HVA) group. They are blocked by dihydropyridines(DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA(omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA(omega-CTx-GVIA) and omega-agatoxin-IVA(omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

calcium channel, voltage-dependent,
L type, alpha 1S subunit


Epitope

IgG

Isotype

IgG

Vial size

100¦Ìg

Concentration

Immunogen affinity purified

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

Handling

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)