ADH1A

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]

Description

Alcohol dehydrogenase 1A (class I), alpha polypeptide

Tissue specificity

Tissue enriched (liver)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (99276369 - 99291003)

Ensembl ID

ENSG00000187758  (ver. 103.38)

Orthologs

-

UniProt

P07327

neXtProt

NX_P07327

Human splice variants

Protein structure