Tissue expression
Cell line expression
Protein structure
GCLC
Glutamate-cysteine ligase catalytic subunitGCS, GLCL, GLCLC
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct 2010]
Top validated antibodies |
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Proteintech Group | 12601-1-AP | 113 references | Polyclonal |
WB
EL
IP
IHC |
|
antibodies-online | ABIN952477 | 3 references | Polyclonal |
WB
ICC
IHC
FC |
|
Novus Biologicals | H00002729-M01 | 13 references | Monoclonal |
WB
EL
ICC
|
|
Abnova Corporation | H00002729-M01 | 6 references | Monoclonal |
WB
EL
ICC
|
|
OriGene | AP51800PU-N | Polyclonal |
WB
ICC
IHC
FC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider