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Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [17]
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- Western blot [2]
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- Product number
- NB100-477 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-477, RRID:AB_10000486
- Product name
- Mouse Monoclonal XPC Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 ul
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC.
Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics.
ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency.
Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue.
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC).
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.
Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes.
The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas.
Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells.
SUMO-dependent regulation of centrin-2.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.
Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63.
Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice.
DDB1 maintains genome integrity through regulation of Cdt1.
Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53.
Fast OG, Gentry B, Strouth L, Niece MB, Beckford FA, Shell SM
Bioscience reports 2019 Jul 31;39(7)
Bioscience reports 2019 Jul 31;39(7)
Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics.
Beresova L, Vesela E, Chamrad I, Voller J, Yamada M, Furst T, Lenobel R, Chroma K, Gursky J, Krizova K, Mistrik M, Bartek J
Journal of proteome research 2016 Dec 2;15(12):4505-4517
Journal of proteome research 2016 Dec 2;15(12):4505-4517
ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency.
Mohni KN, Kavanaugh GM, Cortez D
Cancer research 2014 May 15;74(10):2835-45
Cancer research 2014 May 15;74(10):2835-45
Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue.
Berra CM, de Oliveira CS, Garcia CC, Rocha CR, Lerner LK, Lima LC, Baptista Mda S, Menck CF
Free radical biology & medicine 2013 Aug;61:343-56
Free radical biology & medicine 2013 Aug;61:343-56
Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.
Kothandapani A, Gopalakrishnan K, Kahali B, Reisman D, Patrick SM
Experimental cell research 2012 Oct 1;318(16):1973-86
Experimental cell research 2012 Oct 1;318(16):1973-86
Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC).
Muenyi CS, States VA, Masters JH, Fan TW, Helm CW, States JC
Journal of ovarian research 2011 Jun 22;4:9
Journal of ovarian research 2011 Jun 22;4:9
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.
Takedachi A, Saijo M, Tanaka K
Molecular and cellular biology 2010 Jun;30(11):2708-23
Molecular and cellular biology 2010 Jun;30(11):2708-23
Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes.
Rezvani HR, Mahfouf W, Ali N, Chemin C, Ged C, Kim AL, de Verneuil H, Taïeb A, Bickers DR, Mazurier F
Nucleic acids research 2010 Jan;38(3):797-809
Nucleic acids research 2010 Jan;38(3):797-809
The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas.
de Feraudy S, Ridd K, Richards LM, Kwok PY, Revet I, Oh D, Feeney L, Cleaver JE
The American journal of pathology 2010 Aug;177(2):555-62
The American journal of pathology 2010 Aug;177(2):555-62
Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells.
Acu ID, Liu T, Suino-Powell K, Mooney SM, D'Assoro AB, Rowland N, Muotri AR, Correa RG, Niu Y, Kumar R, Salisbury JL
Cancer research 2010 Apr 15;70(8):3320-8
Cancer research 2010 Apr 15;70(8):3320-8
SUMO-dependent regulation of centrin-2.
Klein UR, Nigg EA
Journal of cell science 2009 Sep 15;122(Pt 18):3312-21
Journal of cell science 2009 Sep 15;122(Pt 18):3312-21
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.
Wang Y, Liu X, Matsuda A, Plunkett W
Cancer research 2008 May 15;68(10):3881-9
Cancer research 2008 May 15;68(10):3881-9
Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63.
Ferguson-Yates BE, Li H, Dong TK, Hsiao JL, Oh DH
Carcinogenesis 2008 Jan;29(1):70-5
Carcinogenesis 2008 Jan;29(1):70-5
Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice.
Laposa RR, Huang EJ, Cleaver JE
Proceedings of the National Academy of Sciences of the United States of America 2007 Jan 23;104(4):1389-94
Proceedings of the National Academy of Sciences of the United States of America 2007 Jan 23;104(4):1389-94
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
Molecular and cellular biology 2006 Nov;26(21):7977-90
Molecular and cellular biology 2006 Nov;26(21):7977-90
Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53.
Ferguson BE, Oh DH
Cancer research 2005 Oct 1;65(19):8723-9
Cancer research 2005 Oct 1;65(19):8723-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: XPC Antibody (3.26) [NB100-477] - HeLa whole cell lysate detected using rabbit polyclonal .
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: XPC Antibody (3.26) [NB100-477] - Whole cell extracts (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with XPC antibody [3.26] diluted at 1:500.
