12957-1-AP

antibody from Proteintech Group

Targeting: DNM1L DRP1, DVLP, DYMPLE, HDYNIV, VPS1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

12957-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#12957-1-AP, RRID:AB_2093525

Product name

DRP1 (C-terminal) antibody

Antibody type

Polyclonal

Description

KD/KO validated DRP1 (C-terminal) antibody (Cat. #12957-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis.

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CHIP protects against MPP⁺/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.

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Fei M, Zhang L, Wang H, Zhu Y, Niu W, Tang T, Han Y
Frontiers in oncology 2020;10:516746

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Arsenic (III) and/or copper (II) induces oxidative stress in chicken brain and subsequent effects on mitochondrial homeostasis and autophagy.

Liu Y, Zhao H, Wang Y, Guo M, Mu M, Xing M
Journal of inorganic biochemistry 2020 Oct;211:111201

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PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.

Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913

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HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.

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Wang Z, Xu JH, Mou JJ, Kong XT, Zou JW, Xue HL, Wu M, Xu LX
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ChREBP-β regulates thermogenesis in brown adipose tissue.

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Zhou BH, Wei SS, Jia LS, Zhang Y, Miao CY, Wang HW
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Wang D, Zong C, Cheng K
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Anti-insulin resistance effects of salidroside through mitochondrial quality control.

You B, Dun Y, Zhang W, Jiang L, Li H, Xie M, Liu Y, Liu S
The Journal of endocrinology 2020 Feb;244(2):383-393

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PRCC-TFE3 regulates migration and invasion of translocation renal cell carcinomas via activation of Drp1-dependent mitochondrial fission.

Wang B, Gan W, Han X, Li D
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Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK
PLoS biology 2020 Aug;18(8):e3000808

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Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function.

Wu G, Xiong Q, Wei X, Wang Y, Hu X, He G, Liu L, Lai Q, Dai Z, Anushesh D, Xu Y
PeerJ 2019;7:e7209

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Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.

Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762

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Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss.

Lin H, Xiong H, Su Z, Pang J, Lai L, Zhang H, Jian B, Zhang W, Zheng Y
Frontiers in cellular neuroscience 2019;13:550

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Destruction of redox and mitochondrial dynamics co-contributes to programmed cell death in chicken kidney under arsenite or/and copper (II) exposure.

Zhao H, Wang Y, Fei D, Guo M, Yang X, Mu M, Yu H, Xing M
Ecotoxicology and environmental safety 2019 Sep 15;179:167-174

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Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D
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Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells.

Tang F, Zhang R, Wang J
International journal of molecular sciences 2019 Mar 11;20(5)

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Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens.

Li S, Zhao H, Wang Y, Shao Y, Liu J, Xing M
Poultry science 2019 Feb 1;98(2):734-744

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Copper-Mediated Mitochondrial Fission/Fusion Is Associated with Intrinsic Apoptosis and Autophagy in the Testis Tissues of Chicken.

Shao Y, Zhao H, Wang Y, Liu J, Zong H, Xing M
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Theranostics 2017;7(17):4192-4203

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Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.

Dun Y, Liu S, Zhang W, Xie M, Qiu L
Oxidative medicine and cellular longevity 2017;2017:8024857

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Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.

Xu W, Yu H, Ma R, Ma L, Liu Q, Shan H, Wu C, Zhang R, Zhou Y, Shan H
Oncotarget 2017 Nov 21;8(59):100034-100044

---

ABT737 induces mitochondrial pathway apoptosis and mitophagy by regulating DRP1-dependent mitochondrial fission in human ovarian cancer cells.

Yu Y, Xu L, Qi L, Wang C, Xu N, Liu S, Li S, Tian H, Liu W, Xu Y, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Dec;96:22-29

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The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.

Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497

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Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.

Xu Z, Jin X, Pan T, Liu T, Wan N, Li S
Oncotarget 2017 Aug 8;8(32):52629-52641

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Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state.

Sun A, Wang Y, Liu J, Yu X, Sun Y, Yang F, Dong S, Wu J, Zhao Y, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:36

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Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.

Wu H, Yang P, Hu W, Wang Y, Lu Y, Zhang L, Fan Y, Xiao H, Li Z
Oncotarget 2016 Nov 22;7(47):78069-78082

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Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission.

Wu H, Wang Y, Wu C, Yang P, Li H, Li Z
Journal of agricultural and food chemistry 2016 Dec 14;64(49):9356-9367

---

Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis.

Li S, Wang J, Zhou A, Khan FA, Hu L, Zhang S
Oncotarget 2016 Aug 30;7(35):56002-56012

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Unravelling the proteome of adult rhesus monkey ovaries.

He H, Teng H, Zhou T, Guo Y, Wang G, Lin M, Sun Y, Si W, Zhou Z, Guo X, Huo R
Molecular bioSystems 2014 Mar 4;10(3):653-62

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Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis.

Wang Y, Pan Y, Price A, Martin LJ
Molecular neurodegeneration 2011 Nov 2;6:75

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The DRP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DRP1. This antibody recognizes human antigen. The DRP1 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

12957-1-AP.pdf

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