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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- NB110-55237 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB110-55237, RRID:AB_828809
- Product name
- Rabbit Polyclonal DRP1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures.
Atypical mitochondrial fission upon bacterial infection.
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Sensory neuropathy attributable to loss of Bcl-w.
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation.
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Zou P, Liu L, Zheng LD, Payne KK, Manjili MH, Idowu MO, Zhang J, Schmelz EM, Cheng Z
Oxidative medicine and cellular longevity 2016;2016:4085727
Oxidative medicine and cellular longevity 2016;2016:4085727
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
Chen SD, Zhen YY, Lin JW, Lin TK, Huang CW, Liou CW, Chan SH, Chuang YC
CNS neuroscience & therapeutics 2016 Dec;22(12):988-999
CNS neuroscience & therapeutics 2016 Dec;22(12):988-999
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W
PLoS genetics 2014 Oct;10(10):e1004579
PLoS genetics 2014 Oct;10(10):e1004579
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B
Circulation 2014 Aug 12;130(7):554-64
Circulation 2014 Aug 12;130(7):554-64
Mitochondrial dynamics associated with oxygen-glucose deprivation in rat primary neuronal cultures.
Wappler EA, Institoris A, Dutta S, Katakam PV, Busija DW
PloS one 2013;8(5):e63206
PloS one 2013;8(5):e63206
Atypical mitochondrial fission upon bacterial infection.
Stavru F, Palmer AE, Wang C, Youle RJ, Cossart P
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 1;110(40):16003-8
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 1;110(40):16003-8
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.
Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C, Archer SL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2175-86
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2175-86
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL
Circulation research 2012 May 25;110(11):1484-97
Circulation research 2012 May 25;110(11):1484-97
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Manczak M, Sesaki H, Kageyama Y, Reddy PH
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Biochimica et biophysica acta 2012 Jun;1822(6):862-74
Sensory neuropathy attributable to loss of Bcl-w.
Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1624-34
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Feb 2;31(5):1624-34
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.
Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH
Human molecular genetics 2011 Dec 1;20(23):4515-29
Human molecular genetics 2011 Dec 1;20(23):4515-29
Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation.
Thomas M, Felcht M, Kruse K, Kretschmer S, Deppermann C, Biesdorf A, Rohr K, Benest AV, Fiedler U, Augustin HG
The Journal of biological chemistry 2010 Jul 30;285(31):23842-9
The Journal of biological chemistry 2010 Jul 30;285(31):23842-9
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF
Nature medicine 2009 Nov;15(11):1307-11
Nature medicine 2009 Nov;15(11):1307-11
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: DRP1 Antibody [NB110-55237] - Simple Western lane view shows a specific band for DRP1 in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: DRP1 Antibody [NB110-55237] - Staining of DRP-1 in mouse embryonic fibroblast post-nuclear extracts. Image courtesy of D. Chan California Institute of Technology.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: DRP1 Antibody [NB110-55237] - DRP1 antibody (1:50) was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: DRP1 Antibody [NB110-55237] - Staining of renal tubular epithelium and visceral epithelial cells of glomeruli in Human kidney cortex. 40X magnification.
