NB110-55288

Navas-Madroñal M, Rodriguez C, Kassan M, Fité J, Escudero JR, Cañes L, Martínez-González J, Camacho M, Galán M
Clinical science (London, England : 1979) 2019 Jul 15;133(13):1421-1438

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.

Maremanda KP, Sundar IK, Rahman I
Toxicology and applied pharmacology 2019 Dec 15;385:114788

Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.

Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4

APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress.

Pan JX, Tang F, Xiong F, Xiong L, Zeng P, Wang B, Zhao K, Guo H, Shun C, Xia WF, Mei L, Xiong WC
Cell death & disease 2018 Oct 22;9(11):1077

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.

Kandimalla R, Manczak M, Yin X, Wang R, Reddy PH
Human molecular genetics 2018 Jan 1;27(1):30-40

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.

Vartanian V, Tumova J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd RS, Sampath H
PloS one 2017;12(7):e0181687

Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers.

Chan YL, Saad S, Al-Odat I, Oliver BG, Pollock C, Jones NM, Chen H
Frontiers in molecular neuroscience 2017;10:33

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347

Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal.

Tarpey MD, Davy KP, McMillan RP, Bowser SM, Halliday TM, Boutagy NE, Davy BM, Frisard MI, Hulver MW
Molecular metabolism 2017 Dec;6(12):1597-1609

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation.

Xu S, Wang P, Zhang H, Gong G, Gutierrez Cortes N, Zhu W, Yoon Y, Tian R, Wang W
Nature communications 2016 Oct 14;7:13189

Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterations.

Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C
Clinical and experimental pharmacology & physiology 2016 Nov;43(11):1107-1114

Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.

Lennon FE, Cianci GC, Kanteti R, Riehm JJ, Arif Q, Poroyko VA, Lupovitch E, Vigneswaran W, Husain A, Chen P, Liao JK, Sattler M, Kindler HL, Salgia R
Scientific reports 2016 Apr 15;6:24578

Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish.

Zhang M, Sun T, Jian C, Lei L, Han P, Lv Q, Yang R, Zhou X, Xu J, Hu Y, Men Y, Huang Y, Zhang C, Zhu X, Wang X, Cheng H, Xiong JW
PloS one 2015;10(7):e0132567

CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling.

Palubinsky AM, Stankowski JN, Kale AC, Codreanu SG, Singer RJ, Liebler DC, Stanwood GD, McLaughlin B
Antioxidants & redox signaling 2015 Aug 20;23(6):535-49

Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting.

Su YC, Chiu HW, Hung JC, Hong JR
Apoptosis : an international journal on programmed cell death 2014 Oct;19(10):1457-70

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons.

Amadoro G, Corsetti V, Florenzano F, Atlante A, Ciotti MT, Mongiardi MP, Bussani R, Nicolin V, Nori SL, Campanella M, Calissano P
Neurobiology of disease 2014 Feb;62:489-507

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.

Tseng AH, Shieh SS, Wang DL
Free radical biology & medicine 2013 Oct;63:222-34

Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancer.

Kawada I, Hasina R, Lennon FE, Bindokas VP, Usatyuk P, Tan YH, Krishnaswamy S, Arif Q, Carey G, Hseu RD, Robinson M, Tretiakova M, Brand TM, Iida M, Ferguson MK, Wheeler DL, Husain AN, Natarajan V, Vokes EE, Singleton PA, Salgia R
Cancer biology & therapy 2013 Jul;14(7):679-91

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
The Journal of biological chemistry 2013 Feb 8;288(6):4436-51

High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects.

Luzzo KM, Wang Q, Purcell SH, Chi M, Jimenez PT, Grindler N, Schedl T, Moley KH
PloS one 2012;7(11):e49217

High-mobility group box 1 is essential for mitochondrial quality control.

Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ 3rd, Lotze MT
Cell metabolism 2011 Jun 8;13(6):701-11

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.

Manczak M, Calkins MJ, Reddy PH
Human molecular genetics 2011 Jul 1;20(13):2495-509

Role of Drp1, a key mitochondrial fission protein, in neuropathic pain.

Ferrari LF, Chum A, Bogen O, Reichling DB, Levine JD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Aug 3;31(31):11404-10

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: DRP1 Antibody [NB110-55288] - Rat spinal cord-DRP1 (81kda). Image from verified customer review.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Simple Western: DRP1 Antibody [NB110-55288] - Image shows a specific band for DUX4 in 0.5 mg/mL of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: DRP1 Antibody [NB110-55288] - Lane 1: DRP1 knockout. Lane 2: DRP1 wildtype MEFs. Stained with NB110-55288 at 1:500.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: DRP1 Antibody [NB110-55288] - Total protein from human HeLa and MCF7 cells, mouse 3T3 cells and rat PC12 cells was separated on a 7.5 % gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/mL anti-DRP1 in blocking buffer and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry: DRP1 Antibody [NB110-55288] - Staining of renal tubular epithelium and visceral epithelial cells of the glomerulus. Human kidney cortex, 40X magnification.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: DRP1 Antibody [NB110-55288] - Analysis of FFPE tissue section of mouse kidney using DRP1 antibody #NB110-55288 at 1:300. The primary antibody bound to DRP1 protein in the tissue section was detected using a HRP labeled secondary antibody and DAB reagent. Nuclei of the cells were counterstained with hematoxylin. This antibody generated a diffused cytoplasmic staining of DRP1 in the epithelial cells of various tubules and in the cells of glomeruli.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow Cytometry: DRP1 Antibody [NB110-55288] - An intracellular stain was performed on HeLa cells with NB110-55288 and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Flow Cytometry: DRP1 Antibody [NB110-55288] - An intracellular stain was performed on HeLa cells with DRP1 Antibody NB110-55288AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 488.